pentobarbital will reduce the extent or effect of amlodipine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.pentobarbital will lower the level or outcome of ketoconazole by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Unfamiliar.pentobarbital will minimize the extent or outcome of imat